Symbol
Name
ID

Itk
IL2 inducible T cell kinase
MGI:96621

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgG level

Decreased circulating antibody level

Autoimmune hemolytic anemia

Decreased proportion of CD4-positive helper T cells

Leukopenia

Hemophagocytosis

Autoimmune thrombocytopenia

Stomatitis

Persistent EBV viremia

Lymphadenopathy

Splenomegaly

Autoimmunity

Recurrent infections

Disease(s) Associated with ITK

lymphoproliferative syndrome 1

Mouse Phenotypes

immune system phenotype

increased CD8-positive, alpha-beta memory T cell proliferation

decreased T cell proliferation

abnormal thymus cell ratio

enlarged spleen

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal positive T cell selection

increased double-negative T cell number

increased germinal center B cell number

decreased B cell number

increased B cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta memory T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased NK T cell number

increased mature gamma-delta T cell number

increased memory T cell number

decreased T cell number

abnormal T cell morphology

abnormal NK T cell morphology

abnormal gamma-delta T cell morphology

abnormal spleen morphology

increased IgE level

abnormal CD4-positive, alpha-beta T cell physiology

abnormal CD8-positive, alpha-beta T cell physiology

abnormal T cell activation

decreased interferon-gamma secretion

increased interferon-gamma secretion

increased interleukin-10 secretion

increased interleukin-13 secretion

decreased interleukin-2 secretion

increased interleukin-4 secretion

increased susceptibility to parasitic infection

Availability

Mouse Genotype

Itk^em1(IMPC)Mbp/Itk^em1(IMPC)Mbp

Itk^m1Btlr/Itk^m1Btlr

Itk^m2Btlr/Itk^m2Btlr

Itk^tm1Lex/Itk^tm1Lex

Itk^tm1Litt/Itk^tm1Litt

Itk^tm1Ljb/Itk^tm1Ljb

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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